An additional consideration of the Working Group, based on the lack of genotoxicity of ethylenethiourea, was that the liver tumours and benign pituitary tumours in mice were also produced by a non-genotoxic mechanism. Recent Activity. These dietary levels of PTU and amitrole were previously shown to produce significant antithyroid effects. Clin Chim Acta. In making its evaluation, the Working Group concluded that ethylenethiourea produces thyroid tumours in mice and rats by a non-genotoxic mechanism, which involves interference with the functioning of thyroid peroxidase resulting in a reduction in circulating thyroid hormone concentrations and increased secretion of thyroid-stimulating hormone.
* High exposure may cause dizziness, sweating, nausea, and increased heart rate and blood pressure. *.
[PDF] Ethylene thiourea thyroid function in two groups of exposed workers. Semantic Scholar
Normal Physiology of the Fetus, Thyroid Gland, and Endocrine Function Ethylene thiourea is a common EDC and of particular concern.
CC16 damage causes a significant change in the levels of this protein.
Amitrole, ethylene thiourea, and mancozeb inhibit thyroid peroxidase; amitrole, ethiozin.
Sign in via your Institution Sign in. The results of this study show elevated urinary ETU in pregnant women living in the vicinity of banana plantations.
Environ Sci Technol. Rev Environ Contam Toxicol, 01 Jan Banana export, primarily to the United States and Europe, is an important economic activity in Costa Rica, constituting 2.
(Ethylene active iodine uptake by the thyroid gland when thiol compounds were administered to rhesus. Ethylenethiourea is used as a vulcanization accelerator in the rubber Ethylenethiourea caused thyroid gland enlargement (goitre) in rats and.
on the thyroid gland observed with adult-only exposure to ethylene thiourea.
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Neoplasms of the Zymbal's gland were marginally increased in rats receiving.
Acinar epithelial cell size and height were not different from control. The underlying mechanism of the changes induced by ethylenethiourea is interference with the functioning of thyroid peroxidase activity. Email alerts Article activity alert.
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A second urine sample obtained from the same woman 6 weeks later was much lower 2. Written informed consent was obtained from each woman.